During balanced growth of cells in culture all extensive properties of the culture — e.g. cell number, total mass, total DNA content — increase exponentially at the same specific growth rate. Therefore, in some average sense, each component of a cell must double between birth and division. For DNA there exists an elaborate mechanism to ensure precise replication of the genetic material and accurate partitioning of identical copies of the genome to the two daughter cells. Do cells possess another mechanism (...) that intentionally relates the timing of cell division to overall increase in cell size, or is the coordination of growth and division an incidental consequence of size‐independent rules for progress through the cell cycle?. (shrink)

Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a complex network of protein interactions that control the activities of cyclin‐dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. Computer simulations are necessary for detailed quantitative comparisons between theory and experiment, but they give little insight into the qualitative dynamics of the control system and how molecular interactions determine the fundamental physiological properties of cell (...) replication. To that end, bifurcation diagrams are a useful analytical tool, providing new views of the dynamical organization of the cell cycle, the role of checkpoints in assuring the integrity of the genome, and the abnormal regulation of cell cycle events in mutants. These claims are demonstrated by an analysis of cell cycle regulation in fission yeast. BioEssays 24:1095–1109, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

United States law recognizes adult reproductive liberty and many states view surrogacy services through that lens. During the COVID-19 pandemic in March, 2020, New York State enacted the Child–Pare...

This book traces the trajectory of John J. McDermott's philosophical career through a selection of his essays. Many were originally occasional pieces and address specific issues in American thought and culture. Together they constitute a mosaic of McDermott's philosophy, showing its roots in an American conception of experience. Though he draws heavily on the thought of William James and the pragmatists, McDermott has his own unique perspective on philosophy and American life. He presents this to the reader in exquisitely (...) crafted prose. Drawing inspiration from American history, from existentialist themes, and from personal experiences, he offers a dramatic consideration of our culture's failures and successes. McDermott crosses disciplinary boundaries to draw on whatever works to help make sense of the issues with which he is dealing--issues rooted in medical practice, political events, pedagogical habits, and the worlds of the arts. His work thus resists simple categorization. It is precisely this that makes his vibrant prose appealing to so many both inside and outside the world of American philosophy. (shrink)

_A groundbreaking examination of a central question in international relations: Do states act rationally?_ To understand world politics, you need to understand how states think. Are states rational? Much of international relations theory assumes that they are. But many scholars believe that political leaders rarely act rationally. The issue is crucial for both the study and practice of international politics, for only if states are rational can scholars and policymakers understand and predict their behavior. John J. Mearsheimer and Sebastian (...) Rosato argue that rational decisions in international politics rest on credible theories about how the world works and emerge from deliberative decision‑making processes. Using these criteria, they conclude that most states are rational most of the time, even if they are not always successful. Mearsheimer and Rosato make the case for their position, examining whether past and present world leaders, including George W. Bush and Vladimir Putin, have acted rationally in the context of momentous historical events, including both world wars, the Cold War, and the post–Cold War era. By examining this fundamental concept in a novel and comprehensive manner, Mearsheimer and Rosato show how leaders think, and how to make policy for dealing with other states. (shrink)

This book reexamines ideas about linguistic relativity in the light of new evidence and changes in theoretical climate.

_A renowned scholar argues that liberal hegemony—the policy America has pursued since the Cold War ended—is doomed to fail__ Named a _Financial Times_ Best Book of 2018__ “Idealists as well as realists need to read this systematic tour de force.”—Robert D. Kaplan, author of ___The Return of Marco Polo’s World__ It is widely believed in the West that the United States should spread liberal democracy across the world, foster an open international economy, and build international institutions. The policy of remaking (...) the world in America’s image is supposed to protect human rights, promote peace, and make the world safe for democracy. But this is not what has happened. Instead, the United States has become a highly militarized state fighting wars that undermine peace, harm human rights, and threaten liberal values at home. In this major statement, the renowned international-relations scholar John Mearsheimer argues that liberal hegemony—the foreign policy pursued by the United States since the Cold War ended—is doomed to fail. It makes far more sense, he maintains, for Washington to adopt a more restrained foreign policy based on a sound understanding of how nationalism and realism constrain great powers abroad. _The Great Delusion _is a lucid and compelling work of the first importance for scholars, policymakers, and everyone interested in the future of American foreign policy. (shrink)

This is done through a chronology, an introductory essay, an extensive bibliography, and hundreds of cross-referenced dictionary entries on key terms and...

John J. Stuhr, a leading voice in American philosophy, sets forth a view of pragmatism as a personal work of art or fashion. Stuhr develops his pragmatism by putting pluralism forward, setting aside absolutism and nihilism, opening new perspectives on democracy, and focusing on love. He creates a space for a philosophy that is liable to failure and that is experimental, pluralist, relativist, radically empirical, radically democratic, and absurd. Full color illustrations enhance this lyrical commitment to a new version (...) of pragmatism. (shrink)

John Clarke of Hull, one of the eighteenth century's staunchest proponents of psychological egoism, defended that theory in his Foundation of Morality in Theory and Practice. He did so mainly by opposing the objections to egoism in the first two editions of Francis Hutcheson's Inquiry into Virtue. But Clarke also produced a challenging, direct argument for egoism which, regrettably, has received virtually no scholarly attention. In this paper I give it some of the attention it merits. In addition to (...) reconstructing it and addressing interpretive issues about it, I show that it withstands a tempting objection. I also show that although Clarke's argument ultimately fails, to study it is instructive. It illuminates, for example, Hutcheson's likely intentions in a passage relevant to egoism. (shrink)

This book examines Aristotle's critical reaction to the mathematical cosmology of Plato's Academy, and traces the aporetic method by which he developed his own...

The salon was of particular importance in mid- to late-seventeenth-century France, enabling aristocratic women to develop a philosophical culture that simultaneously reflected and opposed the dominant male philosophy. In The Suspicion of Virtue, John J. Conley, S. J., explores the moral philosophies developed by five women authors of that milieu: Madame de Sablé, Madame Deshoulières, Madame de la Sablière, Mlle de la Vallière, and Madame de Maintenon. Through biography, extensive translation, commentary, and critical analysis, The Suspicion of Virtue presents (...) the work of women who participated in the philosophical debates of the early modern period but who have been largely erased from the standard history of philosophy. Conley examines the various literary genres (maxim, ode, dialogue) in which these authors presented their moral theory. He also unveils the philosophical complexity of the arguments presented by these women and of the salon culture that nurtured their preoccupations. Their pointed critiques of virtue as a mask of vice, Conley asserts, are relevant to current controversy over the revival of virtue theory by contemporary ethicians. (shrink)

Among the most animating debates in eighteenth-century British ethics was the debate over psychological egoism, the view that our most basic desires are self-interested. An important episode in that debate, less well known than it should be, was the exchange between Francis Hutcheson and John Clarke of Hull. In the early editions of his Inquiry into Virtue, Hutcheson argued ingeniously against psychological egoism; in his Foundation of Morality, Clarke argued ingeniously against Hutcheson’s arguments. Later, Hutcheson attempted new arguments against (...) psychological egoism, designed to overcome Clarke’s objections. This article examines the exchange between these philosophers. Its conclusion, influenced partly by Clarke, is that psychological egoism withstands Hutcheson’s arguments. This is not to belittle those arguments—indeed, they are among the most resourceful and plausible of their kind. The fact that egoism withstands them is thus not a mere negative result, but a stimulus to consider carefully the ways in which progress in this area may be possible. (shrink)

In this article I address a puzzle about one of Francis Hutcheson’s objections to psychological egoism. The puzzle concerns his premise that God receives no benefit from rewarding the virtuous. Why, in the early editions of his Inquiry Concerning Virtue (1725, 1726), does Hutcheson leave this premise undefended? And why, in the later editions (1729, 1738), does he continue to do so, knowing that in 1726 John Clarke of Hull had subjected the premise to plausible criticism, geared to the (...) very audience (mainly Christian) for whom Hutcheson’s objection to egoism was written? This puzzle is not negligible. Some might claim that Hutcheson ruins his objection by ignoring Clarke’s criticism. To answer the puzzle we must consider not only Hutcheson’s philosophy but also some theological assumptions of Hutcheson’s time. (shrink)

In this paper I refute the chief arguments for cultural relativism, meaning the moral (not the descriptive) theory that goes by that name. In doing this I walk some oft-trodden paths, but I also break new ones. For instance, I take unusual pains to produce an adequate formulation of cultural relativism, and I distinguish that thesis from the relativism of present-day anthropologists, with which it is often conflated. In addition, I address not one or two, but eleven arguments for cultural (...) relativism, many of which contribute to its popularity but receive scant attention from its critics. To elicit the failings of these arguments I deploy a host of pertinent but often neglected distinctions. (shrink)

This paper distinguishes between two senses of the term “ phenomenology ”: a narrow sense and a broader sense. It claims, with particular reference to the moral sphere, that the narrow meaning of moral phenomenology cannot stand alone, that is, that moral phenomenology in the narrow sense entails moral intentionality. The paper proceeds by examining different examples of the axiological and volitional experiences of both virtuous and dutiful agents, and it notes the correlation between the phenomenal and intentional differences belonging (...) to these experiences. The paper concludes with some reflections on how the focus on the broader sense of “ phenomenology ” serves to provide a more precise sense of what we might mean by “ moral phenomenology.”. (shrink)

This paper explores two perspectives in Husserl's recently published writings on ethics and axiology in order to sketch anew a phenomenological account of practical reason. The paper aims a) to show that a phenomenological account of moral intentionality i) transcends the disputes between intellectualist-emotivist and intellectualist-voluntarist disputes and ii) points toward a position in which practical reason has an emotive content or, conversely, the emotions have a cognitive content, and the paper aims b) to show that a phenomenological ethics identifies (...) universal human goods that are, nevertheless, specified differently in varying cultural contexts. (shrink)

The role of analogy appears in surprisingly different areas of the first Critique. On the one hand, Kant considered the concept to have a specific enough meaning to entitle the principle concerned with causation an analogy; on the other hand we can find Kant referring to analogy in various parts of the Transcendental Dialectic in a seemingly different manner. Whereas in the Transcendental Analytic, Kant takes some time to provide a detailed (if not clear) account of the meaning of the (...) term ‘analogy’ and his reasons for his employment of it, in the Transcendental Dialectic on the other hand, Kant’s employment of the term seems far less technical. It would seem on the face of it, that Kant has two senses of ‘analogy’: one technical sense reserved for those constitutive principles of the understanding as laid out in the Analytic, and another casual and commonplace use of the term. This picture, although it contains elements of truth, is ultimately misleading. I argue for three claims in this paper. Firstly, I suggest that there can be found in the first Critique a unified conception of analogy. Secondly, I argue that Kant self-consciously differentiated his employment of analogy from the employment that can be found in many early modern philosophers, e.g. Locke. Thirdly, I will tentatively suggest that this interpretation of analogy can aid us in addressing certain contentious areas of transcendental idealism, most notably the account of causation. (shrink)

This article surveys arguments for the claim that employees have a right to strong forms of decision-making participation. Itconsiders objections to employee participation based on shareholders' property rights and it claims that those objections are flawed. In particular, it argues the employee participation rights are grounded on the same values as are property rights. The articlesuggests that the conflict between these two competing rights claims is best resolved by limiting the scope of corporate property rightsand by recognizing a strong employee (...) right to co-determine corporate decisions. (shrink)

When a young boy playing in a wooded area, I tripped over exposed roots extending from the trunk of a tree. I threw my arms out in front of me to break my fall and disturbed a nest of bees. As I lay on the ground, I was repeatedly stung by bees until I could regain my feet and run away. Frightened and in a great deal of pain - that is what I remember most vividly - I walked home. (...) My mother took me to the doctor, who undoubtedly gave me some sort of treatment and medication, but this has been lost to memory. The part of the visit to the doctor's office that I remember is his removing any stingers remaining in me; this too I remember for its pain. The doctor counted more than seventy stings. Although the exact number escapes memory, I believe it was seventy-one. In brief, the descriptive details of the day's experiences elude memory, but the affective dimension - the pain and fear - does not. (shrink)

In discussions of practical reason we often encounter the view that a fact is a reason for an agent to act only if the fact is capable of moving the agent to act. This view figures centrally in many philosophical controversies, and while taken for granted by some, it is vigorously disputed by others. In this essay I show that if the disputed position is correctly interpreted, it is well armored against stock objections and implied by a premise that is (...) not only plausible, but generally accepted by the position's critics. (shrink)

... Dans le De principiis d'Origene, le chapitre 9 du tome II concerne le debut de la creation du monde, c'est-a-dire, selon la perspective de 1'auteur,...

In reworking his Logical Investigations Husserl adopts two positions that were not actually incorporated into later editions of the Investigations but do appear in other writings: a new distinction between signitive and significative intentions, and the claim that even naming and perceiving acts are categorially formed. This paper investigates Husserl's notion of noematic sense and the pure grammatical ' categories ' intimated therein in order to shed light on these new positions. The paper argues that the development of the theories (...) of the noema and of pure grammar allows us to recognize how even merely perceived or named things have a certain categoriality belonging to them, but that this development also requires us to distinguish between an anticipatory categoriality and an articulated categoriality. (shrink)

The opinion of Mr. Justice Francis of the English High Court which denied the parents of Charlie Gard, who had been born with an extremely rare mutation of a genetic disease, the right to take their child to the United States for a proposed experimental treatment occasioned world wide attention including that of the Pope, President Trump, and the US Congress. The case raise anew a debate as old as the foundation of Western medicine on who should decide and on (...) what standard when there is a conflict between a family and the treating physicians over a possible treatment. This paper will explore the different approaches of the British and American courts on the issue and the various proposals from that of John Rawls in his A Theory of Justice to a processed-based approach for resolving such disputes. As carefully crafted as the opinion of Mr Justice Nicholas Francis in the Gard case proved to be, it left commentators unsatisfied. A widespread criticism, captured in an article by Michael Dougherty in The National Review was for the state to ‘get out of the way of the parents trying to act in the best interests of the child’.1 Although he conceded the parents could be adding to the suffering of the child by taking Charlie to America for an experimental therapy and agreed that such a choice ‘may be the wrong decision,’ in Dougherty’s view, it should still be ‘their decision’. Dougherty’s stand was the popular response to the question of ‘Who should decide?’ It fails, however, to propose any rationale for the decision. It provided no norms, no standards and no guidelines for the parents. Their motive could equally well be indifference to the suffering of the child as concern for his well-being. Furthermore, even good, loving parents may make …. (shrink)

Abstract:This essay places the writings of John Lachs in the tradition of classical American philosophy through an appreciative and critical analysis of several central ideas: pluralism, individualism, mediation, meddling, the cost of comfort, and Stoic pragmatism. I focus on the need to move pluralism from the conceptual to practical realm, and on the need for a less self-contained, libertarian, and ultimately Romantic form of individualism. I also stress the importance of viewing philosophies as personal expressions of temperament.

Among the titles are democracy as cooperative inquiry, validating women's experiences pragmatically, and liberal irony and social reform. Paper edition (unseen), $19.95. Annotation copyright by Book News, Inc., Portland, OR.

Some of the most forceful objections to William Wollaston's moral theory come from his early critics, namely, Thomas Bott (1688-1754), Francis Hutcheson (1694-1746), and John Clarke of Hull (1687-1734). These objections are little known, while the inferior objections of Hume, Bentham, and later prominent critics are familiar. This fact is regrettable. For instance, it impedes a robust understanding of eighteenth-century British ethics; also, it fosters a questionable view as to why Wollaston's theory, although at first well received, soon faded (...) in esteem among philosophers. This paper gives Wollaston's early critics some of the attention they deserve. It reconstructs some of their objections to Wollaston's philosophy, addresses replies to those objections, and shows that despite some minor flaws, the objections succeed. A fact that becomes clear is that Wollaston's philosophy had suffered devastating criticism years before Hume wrote anything against it. (shrink)